Dissoflux

Introduction

Dissoflux is a system designed to measure drug dissolution and permeation simultaneously. It measures the movement of an active pharmaceutical ingredient (API) from a dissolution vessel across a specialized membrane. The Dissoflux system uses a lipid-infused membrane to mimic the gastrointestinal tract lining, providing more biologically relevant data.

Product Overview

This system works as an accessory to a standard dissolution tester. It consists of a reusable permeation chamber that sits inside the dissolution vessel. The API dissolves in the dissolution medium and then permeates through the biomimetic membrane into the permeation chamber. A separate stirrer in the chamber ensures uniform concentration. Samples are collected from the permeation chamber using a small cannula. The design of the Dissoflux allows researchers to better understand how a drug might be absorbed in the body.

Key Features

• Simultaneous Testing: Measures dissolution and permeation in a single run.
• Biomimetic Membrane: A specialized lipid-infused membrane mimics the GI tract lining.
• Reusable Permeation Chambers: Different sizes are available for varying media volumes.
• Integrated Stirring: An adjustable speed stirrer (50-150 rpm) maintains uniform concentration in the permeation chamber.
• Micro-sampling: A dedicated cannula allows for accurate sample collection from the permeation chamber.

Technical Specifications

Applications

• In-vitro/in-vivo correlation (IVIVC) studies.
• Predicting oral drug absorption.
• Drug formulation development and optimization.
• Testing of poorly soluble drugs.
• Comparing different drug formulations.

Pricing

Please contact us for consultation and detailed quotation.

Frequently Asked Questions (FAQ)

1. What is Dissoflux used for?

Dissoflux is used to simultaneously measure the rate a drug dissolves and the rate it permeates across a simulated biological membrane.

2. How does the Dissoflux system work?

A drug dissolves in the main dissolution vessel. It then passes through a lipid membrane into an inner chamber. Samples are taken from this inner chamber to measure permeation.

3. What makes the Dissoflux membrane special?

The membrane is infused with a phospholipid solution. This creates a barrier that mimics the lining of the intestine, providing a more biologically relevant measurement of permeation.

4. What equipment is needed to use this system?

The system is designed to be used as an accessory with a standard dissolution tester (USP Apparatus 1 or 2).

5. Why is stirring in the permeation chamber important?

Stirring ensures that the permeated drug is evenly distributed within the chamber, allowing for accurate and consistent sampling.

Conclusion

The Dissoflux system provides a method to obtain dissolution and permeation data at the same time. By simulating intestinal conditions, it helps predict a drug’s performance in the body. Contact us for more information.