Tap density tester ETD-1020x: Pharmacopeia compliance and automated calculations

Determining tapped density is a critical physical test for evaluating the flowability and compressibility of powders, especially in the pharmaceutical industry. The ETD-1020x Tap Density Tester by Electrolab is a high-performance instrument, designed to perform this test accurately, repeatably, and in full compliance with international pharmacopeia standards.

Key features of the ETD-1020x tap density tester

This product is equipped with smart features that automate the process and ensure reliable results.

Strict compliance with USP and ASTM pharmacopeias

The ETD-1020x is designed to fully comply with the methods specified in the United States Pharmacopeia (USP) and ASTM standards. It supports both USP Method 1 (300 taps/min, 14 mm drop height) and USP Method 2 (250 taps/min, 3 mm drop height), offering flexibility and ensuring the validity of your results.

Automation of critical calculations

One of the biggest advantages of the ETD-1020x is its ability to automatically calculate and print out key results after the test. The device will self-calculate Tapped Density, Compressibility Index, and Hausner Ratio, saving users time and eliminating manual calculation errors.

Dual-station design for high throughput

With two stations operating simultaneously, the ETD-1020x allows users to test two samples at the same time, doubling the productivity of the laboratory. The simultaneous tapping and rotating motion ensures that the powder is packed evenly, leading to accurate and highly repeatable results.

Flexible operation and cGMP compliant reporting

The instrument features a 24×2 LCD that clearly displays parameters, supports various cylinder sizes (10ml, 100ml, 250ml), and allows setting the number of taps up to 9999. The printer port enables the output of cGMP-compliant reports, complete with date and time information, ensuring data integrity.

Detailed technical specifications

• Model: ETD-1020x

• Number of stations: 2

• USP Method 1: 300 strokes/minute, drop height 14 mm ± 1 mm

• USP Method 2: 250 strokes/minute, drop height 3 mm ± 0.2 mm

• Number of taps: 1 – 9999

• Display: 24 x 2 character LCD

• Connectivity: Serial port for printer

• Compatible Cylinders: 10ml, 100ml, 250ml

Frequently asked questions (FAQ)

1. What is Tapped Density?
Tapped density is the bulk density of a powder after it has been compacted under standard conditions (tapped a specific number of times). It is used along with bulk density to evaluate the flowability and compressibility of a powder.

2. What is the difference between USP Method 1 and USP 2?
The main difference lies in the tapping speed and height. USP 1 uses a speed of 300 taps/min with a 14 mm drop height, creating a greater compaction force. USP 2 uses a speed of 250 taps/min with a drop height of only 3 mm, creating a gentler compaction force. The choice of method depends on the powder’s characteristics and the specific monograph.

3. Why is the simultaneous rotating and tapping motion important?
This motion ensures that the surface of the powder bed remains level throughout the tapping process. Without rotation, the powder could shift to one side, leading to an inaccurate volume reading and incorrect results.

4. What indices does the machine calculate automatically?
After the user inputs the powder weight and initial volume, the machine automatically calculates:

• Tapped Density

• Compressibility Index

• Hausner Ratio

5. Is this machine 21 CFR Part 11 compliant?
Based on the information provided, the machine is cGMP compliant with the ability to print reports with date and time. However, the documentation does not mention 21 CFR Part 11 compliance with features like audit trails or electronic signatures.